Sedgwick County is located at the crossroads of Interstate 80 and Interstate 76.
I-76 runs through Sedgwick County from the northeast corner to the middle of the county’s western border. I-76 connects to I-80, a major east-west thoroughfare, about two miles from the northeast corner of the county.
Highway 385 runs throughout the eastern part of the county from its southern border to Julesburg, then northwest into Nebraska. Highway 138 runs east-west through the county along the north side of the South Platte River.
The Union Pacific Railroad runs through the northeastern part of the county.
Julesburg has a municipal airport with lighted runways. Sedgwick County is about 2 ½ hours from Denver International Airport.